The Bison, also known as the Buffalo, is a large, even-toed ungulates, or a species of wild cattle. Measuring almost 3 meters long and weighing a ton, it is among the most famous animals in North America as well as among the many Holocene animals found at the park. It first appeared during the Pleistocene.

Having once roamed North America in vast herds, they became nearly extinct by a combination of commercial hunting and slaughter in the 19th century and introduction of bovine diseases from domestic cattle. With a population in excess of 60 million in the late 18th century, the species was down to 541 animals by 1889. Recovery efforts expanded in the mid-20th century, with a resurgence to roughly 31,000 animals today, largely restricted to a few national parks and reserves.

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